The USB-6421 (mioDAQ) is a USB Type-C bus-powered mioDAQ device with analog I/O, digital I/O, and four counters. It features analog input channels with four input range settings from 200 mV to 10 V, and analog output channels that can output 10 V with update rates of 250 kS/s/ch. Additionally, the USB-6421 digital I/O channels can function as static input or output channels, hardware-timed channels up to 10 MHz, or as triggers, clocks, or I/O for the four onboard counters. The USB-6421 also supports FlexLogger Lite, free data acquisition software from NI, and includes documented APIs and examples for LabVIEW, Python, C/C++, and more.